When you find a partially infected employee or weaken the infection of an enemy with the Crystal pistol, you have two choices: you can heal them, or you can drain them. Similar to the decisions regarding the Little Sisters in BioShock, these choices will have long term effects.
Healing the employees will not give you a lot of rewards at that moment, but as you heal more of them, they will help you in various ways. One example is exclusive Plugins, recieved through PCs found in offices. You will also recieve helpful hints as to the locations of offices and labs via the TeleComm (telepathic communicator).
Draining the employees will provide a major boost to your maximum health and energy levels. Enemies will also be more cautious in attacking you.
Like BioShock, or rather, BioShock 2, the choices you make will determine how the game ends. If you Heal every employee, the ending will be positive. If you Drain all of them, the ending will be negative. If you Heal some and Drain some, you will have to make a choice in the end to determine between two "Neutral" endings. Depending on what choice you make, the ending will be either "Neutral Positive" or "Neutral Negative".
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